Recombinant Human Wiskott-Aldrich syndrome protein family member 3 (WASF3)

Uniprot Id

Q9UPY6

Target Species

Human

Target Name

WASF3

Target Full Name

Actin-binding protein WASF3

Target Function

Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Target Subcellular Location

Cytoplasm, cytoskeleton.

Target Protein Families

SCAR/WAVE family

Target Tissue Specificity

Expressed in ovary and brain.

Target Synonyms

KIAA0900; Protein WAVE-3; Protein WAVE3; SCAR3; Verprolin homology domain containing protein 3; Verprolin homology domain-containing protein 3; WASF3; WASF3_HUMAN; WASP family protein member 3; WAVE3; Wiskott Aldrich syndrome protein family member 3; Wiskott-Aldrich syndrome protein family member 3

Target Background

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. A pseudogene of this gene have been defined on chromosome 6. Alternative splicing results in multiple transcript variants