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| Cat.No | ACP15478 | Target Name | XYLT1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q86Y38 |
|---|
Uniprot Id
Q86Y38
Target Species
Human
Target Name
XYLT1
Target Full Name
Xylosyltransferase 1
Target Function
Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein. Required for normal embryonic and postnatal skeleton development, especially of the long bones. Required for normal maturation of chondrocytes during bone development, and normal onset of ossification.
Target Involvement
Desbuquois dysplasia 2 (DBQD2); Pseudoxanthoma elasticum (PXE)
Target Subcellular Location
Golgi apparatus membrane; Single-pass type II membrane protein. Secreted.
Target Protein Families
Glycosyltransferase 14 family, XylT subfamily
Target Tissue Specificity
Widely expressed. Expressed at higher level in placenta, kidney and pancreas. Weakly expressed in skeletal muscle.
Target Synonyms
Beta D xylosyltransferase 1; O xylosyltransferase 1; Peptide O-xylosyltransferase 1; PXYLT1; UDP-D-xylose:proteoglycan core protein; XT-I; XT1; XTI; Xylosyltransferase 1; Xylosyltransferase I; xylosyltransferase iota; XylT-I; XYLT1; XYLT1_HUMAN
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