Recombinant Human Zinc finger BED domain-containing protein 1 (ZBED1), Truncated

Cat.No	ACP04519	Target Name	ZBED1
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-210aa	Mol Weight	50.8kDa
Protein Length	Partial	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP04519

Target Name

ZBED1

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-210aa

Mol Weight

50.8kDa

Protein Length

Partial

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O96006

Background Information

Uniprot Id

O96006
Target Species

Human
Target Name

ZBED1
Target Full Name

E3 SUMO-protein ligase ZBED1
Target Function

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA. This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12. The resulting increased transcriptional activity drives cell proliferation. Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins.; (Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection.
Target Subcellular Location

Nucleus, PML body. Nucleus.; Nucleus, PML body.
Target Tissue Specificity

Ubiquitously expressed at low levels. Expression is highest in skeletal muscle, heart, spleen and placenta.
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

Ac like transposable element; ALTE; BED type zinc finger domain containing protein 1; DNA replication related element binding factor; dREF homolog; hDREF; KIAA0785; Putative Ac like transposon; Putative Ac-like transposable element; TRAMP; ZBED1; ZBED1_HUMAN; Zinc finger BED domain-containing protein 1; Zinc finger BED type containing 1
Target Background

This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.

Recombinant Human Zinc finger BED domain-containing protein 1 (ZBED1), Truncated

Specifications

Immunogen Information

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