Recombinant Human Zinc finger protein 238 (ZNF238)

Uniprot Id

Q99592

Target Species

Human

Target Name

ZBTB18

Target Full Name

Zinc finger and BTB domain-containing protein 18

Target Function

Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.

Target Involvement

Mental retardation, autosomal dominant 22 (MRD22)

Target Subcellular Location

Nucleus. Note=Associates with condensed chromatin.

Target Protein Families

Krueppel C2H2-type zinc-finger protein family, ZBTB18 subfamily

Target Tissue Specificity

Lymphoid tissues, testis, heart, brain, skeletal muscle, and pancreas and, at much lower level, other tissues.

Target Synonyms

C2H2171; 58 kDa repressor protein; C2H2 171; RP58; TAZ 1; TAZ-1; TAZ1; Transcriptional repressor RP58; Translin associated zinc finger protein 1; Translin-associated zinc finger protein 1; ZBTB18; Zinc finger and BTB domain containing protein 18; Zinc finger and BTB domain-containing protein 18; Zinc finger protein 238; Zinc finger protein C2H2 171; Zinc finger protein C2H2-171; ZN238_HUMAN; ZNF238