Recombinant Human Zinc finger protein 683 (ZNF683)

Cat.No	ACP19443	Target Name	ZNF683
Target Synonyms	MGC33414; RP11 569G9.6; Zinc finger protein 683; ZN683_HUMAN; ZNF 683; ZNF683	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-524
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP19443

Target Name

ZNF683

Target Synonyms

MGC33414; RP11 569G9.6; Zinc finger protein 683; ZN683_HUMAN; ZNF 683; ZNF683

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-524

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q8IZ20

Background Information

Uniprot Id

Q8IZ20
Target Species

Human
Target Name

ZNF683
Target Full Name

Tissue-resident T-cell transcription regulator protein ZNF683
Target Function

Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Plays also a role in the differentiation of both thymic and peripheral NKT cells. Negatively regulates the accumulation of interferon-gamma (IFN-gamma) in NKT cells at steady state or after antigenic stimulation. Positively regulates granzyme B production in NKT cells after innate stimulation. Associates with the transcriptional repressor PRDM1/BLIMP1 to chromatin at gene promoter regions.; Lacks transcriptional repressor activity. Binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Unable to regulate interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T-cells.; Transcriptional repressor that binds to DNA within promoter regions of the transcriptional repressor PRDM1/BLIMP1 target sites. Regulates interferon-gamma (IFN-gamma) production in cytomegalovirus (CMV)-infected effector CD8(+) T cells
Target Subcellular Location

Nucleus.
Target Protein Families

Krueppel C2H2-type zinc-finger protein family
Target Tissue Specificity

Expressed in terminally differentiated effector CD8(+) T-cells, but not in naive and central memory cells. Expressed in terminally differentiated natural killer (NK) cells and natural killer (NKT) T-cells (at protein level). Expressed strongly in effector
Target Synonyms

MGC33414; RP11 569G9.6; Zinc finger protein 683; ZN683_HUMAN; ZNF 683; ZNF683

Recombinant Human Zinc finger protein 683 (ZNF683)

Specifications

Immunogen Information

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