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Recombinant Human Zinc finger protein Eos (IKZF4)

ACP10357

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Specifications

Cat.No	ACP10357	Target Name	IKZF4
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-585	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9H2S9

Background Information

Uniprot Id

Q9H2S9
Target Species

Human
Target Name

IKZF4
Target Full Name

Zinc finger protein Eos
Target Function

DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1.
Target Subcellular Location

Nucleus.
Target Protein Families

Ikaros C2H2-type zinc-finger protein family
Target Tissue Specificity

Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of my
Target Synonyms

EOS; Eos protein; IKAROS family zinc finger 4 (Eos) ; IKAROS family zinc finger 4; Ikaros family zinc finger protein 4; IKZF4; IKZF4_HUMAN; KIAA1782; Zinc finger protein Eos (IKAROS family zinc finger protein 4); Zinc finger protein Eos; Zinc finger protein; subfamily 1A; 4 (Eos); Zinc finger protein; subfamily 1A; member 4; Zinc finger transcription factor Eos; ZNFN1A4

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Recombinant Human Zinc finger protein Eos (IKZF4)

Specifications

Immunogen Information

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