Recombinant Human Zona pellucida sperm-binding protein 1 (ZP1)

Uniprot Id

P60852

Target Species

Human

Target Name

ZP1

Target Full Name

Zona pellucida sperm-binding protein 1

Target Function

Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida.

Target Involvement

Oocyte maturation defect 1 (OOMD1)

Target Subcellular Location

[Processed zona pellucida sperm-binding protein 1]: Zona pellucida.; Cell membrane; Single-pass type I membrane protein.

Target Protein Families

ZP domain family, ZPB subfamily

Target Tissue Specificity

Expressed in oocytes (at protein level).

Target Synonyms

MGC87693; Processed zona pellucida sperm-binding protein 1; zona pellucida glycoprotein 1 (sperm receptor); Zona pellucida glycoprotein 1; zona pellucida protein 1; Zp 1; Zp-1; Zp1; ZP1_HUMAN

Target Background

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility.