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The recombinant antibody against SAE1 was produced using a synthesized peptide derived from human SAE1 as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB, IF.
The recombinant antibody against SAE1 was produced using a synthesized peptide derived from human SAE1 as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB, IF.
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Western Blot | Positive WB detected in: K562 whole cell lysate | All lanes: SAE1 Antibody at 1:1000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 39, 30, 34 kDa | Observed band size: 39 kDa
| Cat.No | ADC-56794A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | SAE1 | Target Synonyms | AOS1 SUA1 UBLE1A, N-terminally processed], SAE1, SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | Rabbit IgG | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline |
| Purification Method | Affinity-chromatography purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, WB | Storage | Upon receipt |
| Immunogen Description | A synthesized peptide derived from human SAE1 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UBE0 |
Uniprot Id
Q9UBE0
Target Species
Human
Target Name
SAE1
Target Full Name
SUMO-activating enzyme subunit 1
Target Function
The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2.
Target Subcellular Location
Nucleus.
Target Protein Families
Ubiquitin-activating E1 family
Target Tissue Specificity
Expression level increases during S phase and drops in G2 phase (at protein level).
Target Research Area
Cell Biology
Target Synonyms
Activator of SUMO1; AOS1; HSPC140; Sae1; SAE1_HUMAN; Sentrin/SUMO activating protein AOS1; SUA1; SUMO 1 activating enzyme E1 N subunit; SUMO 1 activating enzyme subunit 1; SUMO-activating enzyme subunit 1; Ubiquitin like protein SUMO1 activating enzyme; Ubiquitin-like 1-activating enzyme E1A; UBL E1A; UBLE1A
Target Background
Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).
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