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The antibody against ICSA was raised in rabbit using the Recombinant Shigella flexneri ICSA protein (311-547aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Protein G Purified. This antibody has been validated on ELISA, WB.
The antibody against ICSA was raised in rabbit using the Recombinant Shigella flexneri ICSA protein (311-547aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Protein G Purified. This antibody has been validated on ELISA, WB.
$299.00
Western Blot | Positive WB detected in Recombinant protein | All lanes: ICSA antibody at 1:2000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 40.3 kDa | Observed band size: 45 kDa
| Cat.No | ADC-55351A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ICSA |
| Target Synonyms | Outer membrane protein IcsA autotransporter [Cleaved into: Outer membrane protein IcsA; Outer membrane protein IcsA translocator] icsA virG CP0182 | Form | Liquid |
| Species Reactivity | Shigella flexneri | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Shigella flexneri ICSA protein (311-547aa) | Target Species | Shigella flexneri |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q7BCK4 |
Uniprot Id
Q7BCK4
Target Species
Shigella flexneri
Target Name
ICSA
Target Function
Essential for bacterial spreading by eliciting polar deposition of filamentous actin (actin-based motility). Inside the host cell mediates nucleation and polymerization of actin molecules on the bacterial surface, which provides the propulsive force for intracellular movement and intercellular dissemination of the bacterium. During invasion of mammalian cells, triggers autophagy by binding to APG5L. Interaction with IcsB leads to escape from the autophagic host defense system. Also binds ATP and displays weak ATPase activity.
Target Subcellular Location
[Outer membrane protein IcsA autotransporter]: Periplasm.; [Outer membrane protein IcsA]: Secreted. Cell surface. Note=The alpha domain is localized as a cap over the old pole of the bacterial surface.; [Outer membrane protein IcsA translocator]: Cell outer membrane; Multi-pass membrane protein. Note=The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane.
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