Rabbit anti- SLC14A1 Monoclonal Antibody

Uniprot Id

Q13336

Target Species

Human

Target Name

SLC14A1

Target Full Name

Urea transporter 1

Target Function

Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across erythrocyte membranes. May also play a role in transmembrane water transport, possibly by indirect means.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.

Target Protein Families

Urea transporter family

Target Tissue Specificity

Detected in erythrocytes (at protein level). Erythrocytes.

Target Synonyms

blood group Kidd urea transporter; erythrocyte; HsT1341; HUT11; JK; Kidd; kidd (JK) blood group urea transporter B1; RACH1; Slc14a1; solute carrier family 14 (urea transporter) member 1 (Kidd blood group); Solute carrier family 14 member 1; Urea transporter 1; Urea transporter; urea transporter B1; Urea transporter erythrocyte; urea transporter JK glycoprotein; UT B1; UT1; UT1_HUMAN; UTE

Target Background

The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system.