Thap Domain-Containing Protein 1 (THAP1) Reagents

THAP domain-containing protein 1

DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.

Dystonia 6, torsion (DYT6)

Nucleus, nucleoplasm. Nucleus, PML body.

THAP1 family

Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta.

4833431A01Rik; DYT6; FLJ10477; MGC33014; Nuclear proapoptotic factor; THAP 1; THAP domain containing 1; THAP domain containing apoptosis associated protein 1; THAP domain containing protein 1; THAP domain protein 1; THAP domain-containing protein 1; Thap1; THAP1_HUMAN

The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed.