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The generation of the recombinant Human DLGAP5 protein involves manipulating gene expression in e.coli cells. A specific DNA sequence coding for the Human DLGAP5 protein (1-846aa) is inserted to an expression vector, which is then introduced into e.coli cells. The cells that successfully receive the vector are selected and cultured to induce the expression of the desired protein. A N-terminal GST tag is attached to the protein. The recombinant Human DLGAP5 protein undergoes affinity purification, achieving a purity level exceeding 85%, as verified through SDS-PAGE analysis.
The generation of the recombinant Human DLGAP5 protein involves manipulating gene expression in e.coli cells. A specific DNA sequence coding for the Human DLGAP5 protein (1-846aa) is inserted to an expression vector, which is then introduced into e.coli cells. The cells that successfully receive the vector are selected and cultured to induce the expression of the desired protein. A N-terminal GST tag is attached to the protein. The recombinant Human DLGAP5 protein undergoes affinity purification, achieving a purity level exceeding 85%, as verified through SDS-PAGE analysis.
| Cat.No | ACP01089 | Target Name | DLGAP5 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-846aa | Mol Weight | 121.8 kDa |
| Protein Length | Full length | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q15398 |
|---|
Uniprot Id
Q15398
Target Species
Human
Target Name
DLGAP5
Target Full Name
Disks large-associated protein 5
Target Function
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
Target Subcellular Location
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.
Target Protein Families
SAPAP family
Target Tissue Specificity
Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.
Target Research Area
Cancer
Target Synonyms
DAP-5; DAP5; Discs large homolog 7; Disks large associated protein 5; Disks large associated protein DLG7; Disks large-associated protein 5; Disks large-associated protein DLG7; DLG 1; DLG 7; DLG1; DLG7; DLGAP5; DLGP5_HUMAN; Drosophila discs large 1 tumor suppressor like; Hepatoma up regulated protein; Hepatoma up-regulated protein; Hepatoma upregulated protein; HURP; KIAA0008
Target Background
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centrosome localization; kinetochore assembly; and mitotic spindle organization. Located in several cellular components, including centrosome; cytosol; and mitochondrion.
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