Recombinant Human Protein DEK (DEK)

Uniprot Id

P35659

Target Species

Human

Target Name

DEK

Target Full Name

Protein DEK

Target Function

Involved in chromatin organization.

Target Involvement

A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122).

Target Subcellular Location

Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.

Target Tissue Specificity

Ubiquitous. Expressed at relatively high levels.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

D6S231E; Dek; DEK gene; DEK oncogene; DEK oncogene DNA binding; DEK_HUMAN; Protein DEK

Target Background

This gene encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene.