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The region for expressing recombinant Human CACNA2D1 contains amino acids 528-668. The calculated molecular weight for this CACNA2D1 protein is 32.3 kDa. This CACNA2D1 protein is produced using e.coli expression system. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of CACNA2D1, making it easier to detect and purify the CACNA2D1 recombinant protein in the later stages of expression and purification.Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1) is primarily studied in the fields of neurobiology and neuropharmacology. Within nerve cells, CACNA2D1 participates in the formation and regulation of voltage-dependent calcium channels, playing a crucial role in neural signal transmission and neuronal excitability. Research indicates that CACNA2D1 is associated with certain neurological disorders such as epilepsy and neuropathic pain. Scientists are exploring its precise role in the pathogenesis of these diseases, aiming to provide new targets and strategies for their treatment. Additionally, the study of CACNA2D1 extends to the cardiovascular system, particularly its function in cardiac muscle cells. Its regulatory mechanisms in cardiovascular diseases and arrhythmias are also subjects of considerable interest.
The region for expressing recombinant Human CACNA2D1 contains amino acids 528-668. The calculated molecular weight for this CACNA2D1 protein is 32.3 kDa. This CACNA2D1 protein is produced using e.coli expression system. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of CACNA2D1, making it easier to detect and purify the CACNA2D1 recombinant protein in the later stages of expression and purification.Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1) is primarily studied in the fields of neurobiology and neuropharmacology. Within nerve cells, CACNA2D1 participates in the formation and regulation of voltage-dependent calcium channels, playing a crucial role in neural signal transmission and neuronal excitability. Research indicates that CACNA2D1 is associated with certain neurological disorders such as epilepsy and neuropathic pain. Scientists are exploring its precise role in the pathogenesis of these diseases, aiming to provide new targets and strategies for their treatment. Additionally, the study of CACNA2D1 extends to the cardiovascular system, particularly its function in cardiac muscle cells. Its regulatory mechanisms in cardiovascular diseases and arrhythmias are also subjects of considerable interest.
| Cat.No | ACP02037 | Target Name | CACNA2D1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 528-668aa | Mol Weight | 32.3 kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P54289 |
|---|
Uniprot Id
P54289
Target Species
Human
Target Name
CACNA2D1
Target Full Name
Voltage-dependent calcium channel subunit alpha-2/delta-1
Target Function
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling.
Target Subcellular Location
Membrane; Single-pass type I membrane protein.
Target Protein Families
Calcium channel subunit alpha-2/delta family
Target Tissue Specificity
Isoform 1 is expressed in skeletal muscle. Isoform 2 is expressed in the central nervous system. Isoform 2, isoform 4 and isoform 5 are expressed in neuroblastoma cells. Isoform 3, isoform 4 and isoform 5 are expressed in the aorta.
Target Research Area
others
Target Synonyms
CA2D1_HUMAN; CACN A2; CACNA2; Cacna2d1; CACNL2A; Calcium channel L type alpha 2 polypeptide; Calcium channel voltage dependent alpha 2/delta subunit 1; CCHL2A; Dihydropyridine receptor alpha 2 subunit; Dihydropyridine sensitive L type calcium channel alpha 2/delta subunit; Dihydropyridine sensitive L type calcium channel subunits alpha 2/delta; L type calcium channel subunit alpha 2; MHS 3; MHS3; Voltage dependent calcium channel subunit alpha 2/delta 1; Voltage gated calcium channel subunit alpha 2/delta 1; Voltage-dependent calcium channel subunit delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1
Target Background
The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion.
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