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| Cat.No | ACP02203 | Target Name | ATPSCKMT |
|---|---|---|---|
| Target Synonyms | Protein N-lysine methyltransferase FAM173B;hFAM173B | Form | Liquid or Lyophilized powder |
| Expression System | in vitro E.coli expression system | Expression Range | 1-233aa |
| Mol Weight | 32.2 | Protein Length | Full length |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6P4H8 |
|---|
Uniprot Id
Q6P4H8
Target Species
Human
Target Name
ATPSCKMT
Target Full Name
ATP synthase subunit C lysine N-methyltransferase
Target Function
Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. Promotes chronic pain. Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia.
Target Subcellular Location
Mitochondrion membrane; Single-pass membrane protein.
Target Protein Families
FAM173 family
Target Tissue Specificity
Ubiquitously expressed.
Target Research Area
Others
Target Synonyms
ATPSCKMT; FAM173B; ATP synthase subunit C lysine N-methyltransferase; Protein N-lysine methyltransferase FAM173B; hFAM173B
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