Recombinant Human Actin-related protein 2/3 complex subunit 3 (ARPC3), Truncated

Uniprot Id

O15145

Target Species

Human

Target Name

ARPC3

Target Full Name

Actin-related protein 2/3 complex subunit 3

Target Function

Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).

Target Subcellular Location

Cytoplasm, cytoskeleton. Cell projection. Nucleus.

Target Protein Families

ARPC3 family

Target Research Area

Signal Transduction

Target Synonyms

ARPC3; ARC21Actin-related protein 2/3 complex subunit 3; Arp2/3 complex 21 kDa subunit; p21-ARC

Target Background

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene.