Recombinant Human Transmembrane protein 25 (TMEM25)

Uniprot Id

Q86YD3

Target Species

Human

Target Name

TMEM25

Target Full Name

Transmembrane protein 25

Target Function

In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability.

Target Subcellular Location

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.; Late endosome. Lysosome.

Target Tissue Specificity

Expressed throughout the brain with higher levels in the pyramidal cell layer of the hippocampal CA1 and CA3 regions. Also highly expressed iwhith the hippocampal dentate gyrus region and cerebellum and in scattered neurons in the cerebral cortex.

Target Research Area

Cell Biology

Target Synonyms

0610039J01Rik; FLJ14399; Tmem25; TMM25_HUMAN; Transmembrane protein 25

Target Background

Predicted to be involved in negative regulation of excitatory postsynaptic potential and regulation of protein stability. Predicted to be located in late endosome and lysosome.