Recombinant Human Tescalcin (TESC)

Cat.No	ACP04033	Target Name	TESC
Target Synonyms	TESC; CHP3Calcineurin B homologous protein 3; Tescalcin; TSC	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	2-214aa
Mol Weight	40.6kDa	Protein Length	Full Length of Mature Protein
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP04033

Target Name

TESC

Target Synonyms

TESC; CHP3Calcineurin B homologous protein 3; Tescalcin; TSC

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

2-214aa

Mol Weight

40.6kDa

Protein Length

Full Length of Mature Protein

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q96BS2

Background Information

Uniprot Id

Q96BS2
Target Species

Human
Target Name

TESC
Target Full Name

Calcineurin B homologous protein 3
Target Function

Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
Target Subcellular Location

Nucleus. Cytoplasm. Membrane; Lipid-anchor. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle membrane.
Target Protein Families

Calcineurin regulatory subunit family, CHP subfamily
Target Tissue Specificity

Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.
Target Research Area

Signal Transduction
Target Synonyms

TESC; CHP3Calcineurin B homologous protein 3; Tescalcin; TSC
Target Background

Enables calcium ion binding activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of macromolecule metabolic process; and positive regulation of myeloid cell differentiation. Located in several cellular components, including cytosol; lamellipodium; and nucleoplasm.

Recombinant Human Tescalcin (TESC)

Specifications

Immunogen Information

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