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The expression region of this recombinant Human PLXNA4 covers amino acids 25-521. The theoretical molecular weight of the PLXNA4 protein is 60 kDa. The PLXNA4 protein was expressed in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of PLXNA4, making it easier to detect and purify the PLXNA4 recombinant protein in the later stages of expression and purification.Human Plexin-A4 (PLXNA4) is a transmembrane receptor protein that belongs to the plexin family. PLXNA4 plays a crucial role in axon guidance during neural development. It interacts with semaphorins, a family of proteins that mediate repulsive axon guidance cues. Through its signaling activities, PLXNA4 influences neuronal migration and connectivity. Beyond the nervous system, PLXNA4 is also implicated in cancer progression, angiogenesis, and immune responses. The intricate functions of PLXNA4 in various physiological and pathological processes make it a subject of interest in neuroscience, oncology, and immunology research, offering insights into potential therapeutic targets.
The expression region of this recombinant Human PLXNA4 covers amino acids 25-521. The theoretical molecular weight of the PLXNA4 protein is 60 kDa. The PLXNA4 protein was expressed in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of PLXNA4, making it easier to detect and purify the PLXNA4 recombinant protein in the later stages of expression and purification.Human Plexin-A4 (PLXNA4) is a transmembrane receptor protein that belongs to the plexin family. PLXNA4 plays a crucial role in axon guidance during neural development. It interacts with semaphorins, a family of proteins that mediate repulsive axon guidance cues. Through its signaling activities, PLXNA4 influences neuronal migration and connectivity. Beyond the nervous system, PLXNA4 is also implicated in cancer progression, angiogenesis, and immune responses. The intricate functions of PLXNA4 in various physiological and pathological processes make it a subject of interest in neuroscience, oncology, and immunology research, offering insights into potential therapeutic targets.
| Cat.No | ACP04249 | Target Name | PLXNA4 |
|---|---|---|---|
| Target Synonyms | FAYV2820; KIAA1550; PLEXA4; Plexin-A4; PlexinA4; PLXA4_HUMAN; plxna4; PLXNA4A; PLXNA4B; PRO34003; UNQ2820/PRO34003 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 25-521aa |
| Mol Weight | 60.0kDa | Protein Length | partial of BC028744 |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9HCM2 |
|---|
Uniprot Id
Q9HCM2
Target Species
Human
Target Name
PLXNA4
Target Full Name
Plexin-A4
Target Function
Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
Plexin family
Target Synonyms
FAYV2820; KIAA1550; PLEXA4; Plexin-A4; PlexinA4; PLXA4_HUMAN; plxna4; PLXNA4A; PLXNA4B; PRO34003; UNQ2820/PRO34003
Target Background
Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including axon guidance; positive regulation of axonogenesis; and regulation of GTPase activity. Predicted to act upstream of or within several processes, including nervous system development; regulation of axon extension involved in axon guidance; and regulation of negative chemotaxis. Predicted to be located in plasma membrane. Predicted to be part of semaphorin receptor complex. Predicted to be integral component of plasma membrane.
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