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The gene encoding the Human C1QA protein (23-245aa) is incorporated into a plasmid vector to generate recombinant plasmid, which is then introduced into e.coli cells. The e.coli cells containing the recombinant plasmid are selected and cultured under conditions that stimulate the expression of the gene of interest. A N-terminal 6xHis-SUMO tag is attached to the protein. After expression, affinity purification is employed to isolate and purify the recombinant Human C1QA protein from the cell lysate. Denaturing SDS-PAGE is utilized to resolve the resulting recombinant Human C1QA protein, revealing a purity level exceeding 90%.
The gene encoding the Human C1QA protein (23-245aa) is incorporated into a plasmid vector to generate recombinant plasmid, which is then introduced into e.coli cells. The e.coli cells containing the recombinant plasmid are selected and cultured under conditions that stimulate the expression of the gene of interest. A N-terminal 6xHis-SUMO tag is attached to the protein. After expression, affinity purification is employed to isolate and purify the recombinant Human C1QA protein from the cell lysate. Denaturing SDS-PAGE is utilized to resolve the resulting recombinant Human C1QA protein, revealing a purity level exceeding 90%.
| Cat.No | ACP04406 | Target Name | C1QA |
|---|---|---|---|
| Target Synonyms | C1qa; C1QA_HUMAN; Complement C1q subcomponent subunit A; Complement component 1 q subcomponent A chain; Complement component 1 q subcomponent alpha polypeptide; Complement component C1q A chain | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 23-245aa |
| Mol Weight | 39.7kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P02745 |
|---|
Uniprot Id
P02745
Target Species
Human
Target Name
C1QA
Target Full Name
Complement C1q subcomponent subunit A
Target Function
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
Target Involvement
Complement component C1q deficiency (C1QD)
Target Subcellular Location
Secreted.
Target Research Area
Immunology
Target Synonyms
C1qa; C1QA_HUMAN; Complement C1q subcomponent subunit A; Complement component 1 q subcomponent A chain; Complement component 1 q subcomponent alpha polypeptide; Complement component C1q A chain
Target Background
This gene encodes the A-chain polypeptide of serum complement subcomponent C1q, which associates with C1r and C1s to yield the first component of the serum complement system. C1q deficiency is associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains which include 6 A-chains, 6 B-chains, and 6 C-chains. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. Alternate splicing results in multiple transcript variants.
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