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The recombinant Human NRG2 was expressed with the amino acid range of 112-405. The expected molecular weight for the NRG2 protein is calculated to be 34.8 kDa. This protein is generated in a yeast-based system. The NRG2 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant NRG2 protein during the following stages.The human pro-neuregulin-2 (NRG2) is a membrane-bound isoform of the NRG2 protein. pro-NRG2 is initially anchored to the cell membrane. Through proteolytic processing, it can be cleaved to release soluble fragments that act as ligands for ErbB receptor tyrosine kinases. Activation of ErbB receptors triggers intracellular signaling cascades that regulate cell growth, survival, and differentiation. NRG2 is expressed in various tissues, including the nervous system and the heart, suggesting its diverse functions in both neuronal and cardiac development. Research on pro-NRG2 spans neural and cardiovascular biology, exploring its contributions to cellular processes and its potential implications in diseases such as cancer and heart disorders.
The recombinant Human NRG2 was expressed with the amino acid range of 112-405. The expected molecular weight for the NRG2 protein is calculated to be 34.8 kDa. This protein is generated in a yeast-based system. The NRG2 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant NRG2 protein during the following stages.The human pro-neuregulin-2 (NRG2) is a membrane-bound isoform of the NRG2 protein. pro-NRG2 is initially anchored to the cell membrane. Through proteolytic processing, it can be cleaved to release soluble fragments that act as ligands for ErbB receptor tyrosine kinases. Activation of ErbB receptors triggers intracellular signaling cascades that regulate cell growth, survival, and differentiation. NRG2 is expressed in various tissues, including the nervous system and the heart, suggesting its diverse functions in both neuronal and cardiac development. Research on pro-NRG2 spans neural and cardiovascular biology, exploring its contributions to cellular processes and its potential implications in diseases such as cancer and heart disorders.
| Cat.No | ACP04694 | Target Name | NRG2 |
|---|---|---|---|
| Target Synonyms | Divergent of neuregulin 1; Divergent of neuregulin-1; Don 1; DON-1; Neural- and thymus-derived activator for ERBB kinases; Neuregulin 2; Neuregulin-2; NRG-2; Nrg2; NRG2_HUMAN; NTAK; Pro NRG2; Pro-NRG2 | Form | Liquid or Lyophilized powder |
| Expression System | Yeast | Expression Range | 112-405aa |
| Mol Weight | 34.8kDa | Protein Length | Extracellular Domain |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O14511 |
|---|
Uniprot Id
O14511
Target Species
Human
Target Name
NRG2
Target Full Name
Pro-neuregulin-2, membrane-bound isoform
Target Function
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
Target Subcellular Location
[Pro-neuregulin-2, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein.; [Neuregulin-2]: Secreted.
Target Protein Families
Neuregulin family
Target Tissue Specificity
Restricted to the cerebellum in the adult.
Target Research Area
Neuroscience
Target Synonyms
Divergent of neuregulin 1; Divergent of neuregulin-1; Don 1; DON-1; Neural- and thymus-derived activator for ERBB kinases; Neuregulin 2; Neuregulin-2; NRG-2; Nrg2; NRG2_HUMAN; NTAK; Pro NRG2; Pro-NRG2
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