Recombinant Human Sodium channel protein type 11 subunit alpha (SCN11A), Truncated

Uniprot Id

Q9UI33

Target Species

Human

Target Name

SCN11A

Target Full Name

Sodium channel protein type 11 subunit alpha

Target Function

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.

Target Involvement

Neuropathy, hereditary sensory and autonomic, 7 (HSAN7); Episodic pain syndrome, familial, 3 (FEPS3)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Sodium channel (TC 1.A.1.10) family, Nav1.9/SCN11A subfamily

Target Tissue Specificity

Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta.

Target Synonyms

hNaN; NaN; NAV1.9; Peripheral nerve sodium channel 5; PN 5; PN5; SCN 11A; SCN 12A; Scn11a; SCN12A; SCNBA_HUMAN; Sensory neuron sodium channel 2; SNS 2; SNS2; Sodium channel protein type 11 subunit alpha; Sodium channel protein type XI subunit alpha; Sodium channel voltage gated type XI alpha; Sodium channel voltage gated type XI alpha polypeptide; Sodium channel voltage gated type XI alpha subunit; Sodium channel voltage gated type XII alpha polypeptide; Voltage gated sodium channel Nav1.9; Voltage gated sodium channel subunit alpha Nav1.9; Voltage-gated sodium channel subunit alpha Nav1.9