Recombinant Human Probable phospholipid-transporting ATPase IG (ATP11C), Truncated

Uniprot Id

Q8NB49

Target Species

Human

Target Name

ATP11C

Target Full Name

Phospholipid-transporting ATPase IG

Target Function

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane. Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages. Required for B cell differentiation past the pro-B cell stage. Seems to mediate PS flipping in pro-B cells. May be involved in the transport of cholestatic bile acids

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein.

Target Protein Families

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily

Target Tissue Specificity

Widely expressed.

Target Synonyms

AT11C_HUMAN; ATP11C; ATPase class VI type 11C; ATPase IG; ATPase IQ; ATPIG; ATPIQ; phospholipid-transporting ATPase IG; Probable phospholipid-transporting ATPase IG; RP11-197K18.1