Recombinant Human Sodium/myo-inositol cotransporter 2 (SLC5A11), Truncated

Uniprot Id

Q8WWX8

Target Species

Human

Target Name

SLC5A11

Target Full Name

Sodium/myo-inositol cotransporter 2

Target Function

Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Sodium:solute symporter (SSF) (TC 2.A.21) family

Target Tissue Specificity

Highest expression in heart, skeletal muscle, kidney, liver and placenta. Weaker expression in brain, colon, spleen, lung and peripheral blood leukocytes.

Target Synonyms

homolog of rabbit KST1; KST1; Na(+)/myo-inositol cotransporter 2; na+/myo-inositol cotransporter 2; putative sodium-coupled cotransporter RKST1; RKST1; SC5AB_HUMAN; SGLT6; SLC5A11; SMIT2; Sodium-dependent glucose cotransporter; Sodium/glucose cotransporter KST1; Sodium/myo-inositol cotransporter 2; Sodium/myo-inositol transporter 2; solute carrier family 5 (sodium/glucose cotransporter); member 11; Solute carrier family 5 member 11

Target Background

Cotransporters, such as SLC5A11, represent a major class of proteins that make use of ion gradients to drive active transport for the cellular accumulation of nutrients, neurotransmitters, osmolytes, and ions Roll et al. (2002) [PubMed 12039040].