Recombinant Human Oligosaccharyltransferase complex subunit OSTC (OSTC), Truncated

Uniprot Id

Q9NRP0

Target Species

Human

Target Name

OSTC

Target Full Name

Oligosaccharyltransferase complex subunit OSTC

Target Function

Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1

Target Subcellular Location

Endoplasmic reticulum. Membrane; Multi-pass membrane protein.

Target Protein Families

OSTC family

Target Synonyms

OSTC; DC2; HDCMD45P; HSPC307; Oligosaccharyltransferase complex subunit OSTC; Hydrophobic protein HSF-28

Target Background

Predicted to contribute to dolichyl-diphosphooligosaccharide-protein glycotransferase activity. Predicted to be involved in protein N-linked glycosylation via asparagine. Part of oligosaccharyltransferase complex.