Recombinant Human Voltage-gated hydrogen channel 1 (HVCN1), Truncated

Uniprot Id

Q96D96

Target Species

Human

Target Name

HVCN1

Target Full Name

Voltage-gated hydrogen channel 1

Target Function

Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.

Target Subcellular Location

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Detected mainly at intracellular membranes upon overexpression in HeLa cells (PuMed:20147290), but not in other cell types.

Target Protein Families

Hydrogen channel family

Target Tissue Specificity

Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen.

Target Synonyms

HVCN1; VSOP; UNQ578/PRO1140; Voltage-gated hydrogen channel 1; Hydrogen voltage-gated channel 1; HV1; Voltage sensor domain-only protein

Target Background

This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene.