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Recombinant Human Natural resistance-associated macrophage protein 1 (SLC11A1), Truncated

ACP08785

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Specifications

Cat.No	ACP08785	Target Name	SLC11A1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	P49279

Background Information

Uniprot Id

P49279
Target Species

Human
Target Name

SLC11A1
Target Full Name

Natural resistance-associated macrophage protein 1
Target Function

Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
Target Subcellular Location

Membrane; Multi-pass membrane protein.
Target Protein Families

NRAMP family
Target Tissue Specificity

Macrophages; peripheral blood leukocytes, lung, spleen and liver.
Target Synonyms

LSH; Natural resistance associated macrophage protein 1; Natural resistance-associated macrophage protein 1; NRAM1_HUMAN; NRAMP 1; NRAMP; PBC; SLC11A1; Solute carrier family 11 (proton coupled divalent metal ion transporters) member 1; solute carrier family 11 (sodium/phosphate symporters) member 1; Solute carrier family 11 member 1

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Recombinant Human Natural resistance-associated macrophage protein 1 (SLC11A1), Truncated

Specifications

Immunogen Information

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