Recombinant Human Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 (HS3ST3A1), Truncated

Uniprot Id

Q9Y663

Target Species

Human

Target Name

HS3ST3A1

Target Full Name

Heparan sulfate glucosamine 3-O-sulfotransferase 3A1

Target Function

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Target Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Target Protein Families

Sulfotransferase 1 family

Target Tissue Specificity

Ubiquitous. Most abundant in heart and placenta, followed by liver and kidney.

Target Synonyms

HS3ST3A1; 3OST3A1; HS3ST3A; UNQ2551/PRO6180Heparan sulfate glucosamine 3-O-sulfotransferase 3A1; EC 2.8.2.30; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1; 3-OST-3A; Heparan sulfate 3-O-sulfotransferase 3A1; h3-OST-3A

Target Background

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.