Recombinant Human Protein mono-ADP-ribosyltransferase PARP4 (PARP4), Truncated

Uniprot Id

Q9UKK3

Target Species

Human

Target Name

PARP4

Target Full Name

Protein mono-ADP-ribosyltransferase PARP4

Target Function

Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins.

Target Subcellular Location

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle.

Target Tissue Specificity

Widely expressed; the highest levels are in the kidney; also detected in heart, placenta, lung, liver, skeletal muscle, spleen, leukocytes and pancreas.

Target Research Area

Cancer

Target Synonyms

PARP4; ADPRTL1; KIAA0177; PARPL; Protein mono-ADP-ribosyltransferase PARP4; EC 2.4.2.-; 193 kDa vault protein; ADP-ribosyltransferase diphtheria toxin-like 4; ARTD4; PARP-related/IalphaI-related H5/proline-rich; PH5P; Poly [ADP-ribose] polymerase 4; PARP-4; Vault poly(ADP-ribose) polymerase; VPARP

Target Background

This gene encodes poly(ADP-ribosyl)transferase-like 1 protein, which is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. Since this protein is not capable of binding DNA directly, its transferase activity may be activated by other factors such as protein-protein interaction mediated by the extensive carboxyl terminus.