Recombinant Human Poly (A) RNA polymerase, mitochondrial (MTPAP)

Uniprot Id

Q9NVV4

Target Species

Human

Target Name

MTPAP

Target Full Name

Poly(A) RNA polymerase, mitochondrial

Target Function

Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA.

Target Involvement

Spastic ataxia 4, autosomal recessive (SPAX4)

Target Subcellular Location

Cytoplasm. Mitochondrion.

Target Protein Families

DNA polymerase type-B-like family

Target Tissue Specificity

Ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain, and skeletal muscle.

Target Synonyms

0610027A18Rik; AW551379; EC 2.7.7.19; FLJ10486; mitochondrial; Mitochondrial poly(A) polymerase; mtPAP; PAP; PAP-associated domain-containing protein 1; PAPD1; PAPD1_HUMAN; Poly(A) RNA polymerase; Poly(A) RNA polymerase, mitochondrial; Poly(A) RNA polymerase, mitochondrial precursor; Polynucleotide adenylyltransferase; RP11-305E6.3; Terminal uridylyltransferase 1; TUTase 1

Target Background

The protein encoded by this gene is a member of the DNA polymerase type-B-like family. This enzyme synthesizes the 3' poly(A) tail of mitochondrial transcripts and plays a role in replication-dependent histone mRNA degradation.