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| Cat.No | ACP11997 | Target Name | RNF216 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9NWF9 |
|---|
Uniprot Id
Q9NWF9
Target Species
Human
Target Name
RNF216
Target Full Name
E3 ubiquitin-protein ligase RNF216
Target Function
Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis.
Target Involvement
Gordon Holmes syndrome (GDHS)
Target Subcellular Location
Cytoplasm.
Target Tissue Specificity
Ubiquitous, with the highest levels of expression in testis and peripheral blood leukocytes.
Target Synonyms
RNF216; TRIAD3; UBCE7IP1; ZIN; E3 ubiquitin-protein ligase RNF216; EC 2.3.2.27; RING finger protein 216; RING-type E3 ubiquitin transferase RNF216; Triad domain-containing protein 3; Ubiquitin-conjugating enzyme 7-interacting protein 1; Zinc finger protein inhibiting NF-kappa-B
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