Recombinant Human Mediator of RNA polymerase II transcription subunit 4 (MED4)

Uniprot Id

Q9NPJ6

Target Species

Human

Target Name

MED4

Target Full Name

Mediator of RNA polymerase II transcription subunit 4

Target Function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Target Subcellular Location

Nucleus.

Target Protein Families

Mediator complex subunit 4 family

Target Synonyms

Activator-recruited cofactor 36 kDa component; ARC36; DRIP36; FLJ10956; HSPC126; med4; MED4_HUMAN; Mediator complex subunit 4; Mediator of RNA polymerase II transcription subunit 4; Mediator of RNA polymerase II transcription, subunit 4 homolog; OTTHUMP00000018390; OTTHUMP00000018391; OTTHUMP00000018392; RP11-90M2.2; TRAP/SMCC/PC2 subunit p36 subunit; TRAP36; VDRIP; Vitamin D3 receptor-interacting protein complex 36 kDa component

Target Background

This gene encodes a component of the Mediator complex. The Mediator complex interacts with DNA-binding gene-specific transcription factors to modulate transcription by RNA polymerase II. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.