Recombinant Human MIT domain-containing protein 1 (MITD1)

Uniprot Id

Q8WV92

Target Species

Human

Target Name

MITD1

Target Full Name

MIT domain-containing protein 1

Target Function

Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.

Target Subcellular Location

Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Midbody. Membrane; Peripheral membrane protein; Cytoplasmic side. Note=During cytokinesis, recruited to the midbody via interaction with CHMP1A. Interacts with membranes enriched in phosphoinositides.

Target Synonyms

MITD1MIT domain-containing protein 1

Target Background

Abscission, the separation of daughter cells at the end of cytokinesis, is effected by endosomal sorting complexes required for transport III (ESCRT-III). The protein encoded by this gene functions as a homodimer, with the N-termini binding to a subset of ESCRT-III subunits and the C-termini binding to membranes. The encoded protein regulates ESCRT-III activity and is required for proper cytokinesis. Several transcript variants encoding different isoforms have been found for this gene.