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| Cat.No | ACP13394 | Target Name | METTL13 |
|---|---|---|---|
| Target Synonyms | 5630401D24Rik; CGI-01; MET13_HUMAN; Methyltransferase-like protein 13; Mettl13 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-699 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8N6R0 |
|---|
Uniprot Id
Q8N6R0
Target Species
Human
Target Name
METTL13
Target Full Name
eEF1A lysine and N-terminal methyltransferase
Target Function
Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation. Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2'. Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55'. Has no activity towards core histones H2A, H2B, H3 and H4. Negatively regulates cell proliferation at G1/S transition via transcriptional suppression of cell cycle regulatory genes such as CDK4 and CDK6.
Target Subcellular Location
Cytoplasm. Nucleus. Mitochondrion.
Target Protein Families
Methyltransferase superfamily
Target Synonyms
5630401D24Rik; CGI-01; MET13_HUMAN; Methyltransferase-like protein 13; Mettl13
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