Recombinant Human Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (ASZ1)

Uniprot Id

Q8WWH4

Target Species

Human

Target Name

ASZ1

Target Full Name

Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1

Target Function

Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.

Target Subcellular Location

Cytoplasm.

Target Tissue Specificity

Expressed exclusively in the testis and ovary and at higher levels in the adult testis compared with the adult ovary.

Target Synonyms

ASZ1; ALP1; ANKL1; C7orf7; GASZAnkyrin repeat; SAM and basic leucine zipper domain-containing protein 1; Ankyrin-like protein 1; Germ cell-specific ankyrin; SAM and basic leucine zipper domain-containing protein

Target Background

Predicted to be involved in gamete generation and piRNA metabolic process. Predicted to be located in cytoplasm. Predicted to be active in pi-body.