Recombinant Human Ras association domain-containing protein 6 (RASSF6)

Uniprot Id

Q6ZTQ3

Target Species

Human

Target Name

RASSF6

Target Full Name

Ras association domain-containing protein 6

Target Function

Involved in the induction of apoptosis, through both caspase-dependent and caspase-independent pathways. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF-kappa-B.

Target Tissue Specificity

Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the n

Target Research Area

others

Target Synonyms

RASSF6; Ras association domain-containing protein 6

Target Background

This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms.