Recombinant Human Inactive phospholipase C-like protein 1 (PLCL1), Truncated

Cat.No	ACP17724	Target Name	PLCL1
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP17724

Target Name

PLCL1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q15111

Background Information

Uniprot Id

Q15111
Target Species

Human
Target Name

PLCL1
Target Full Name

Inactive phospholipase C-like protein 1
Target Function

Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition. Its aberrant expression could contribute to the genesis and progression of lung carcinoma. Acts as an inhibitor of PPP1C.
Target Subcellular Location

Cytoplasm.
Target Tissue Specificity

Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain.
Target Synonyms

Inactive phospholipase C-like protein 1; Inactive protein 1; Phospholipase C deleted in lung carcinoma; Phospholipase C epsilon; Phospholipase C like 1; Phospholipase C related but catalytically inactive protein; Phospholipase C related, but catalytically inactive protein; Phospholipase C-deleted in lung carcinoma; Phospholipase C-related but catalytically inactive protein; Phospholipase C-related catalytically; PLC-L1; PLCE; PLCL; PLCL1; PLCL1_HUMAN; PLDL1; PRIP
Target Background

Predicted to enable phospholipase C activity. Predicted to be involved in negative regulation of cold-induced thermogenesis and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within several processes, including gamma-aminobutyric acid signaling pathway; regulation of GABAergic synaptic transmission; and regulation of peptidyl-serine phosphorylation. Predicted to be located in cytoplasm and plasma membrane.

Recombinant Human Inactive phospholipase C-like protein 1 (PLCL1), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Inactive phospholipase C-like protein 1 (PLCL1), Truncated Now

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