Recombinant Human AT-rich interactive domain-containing protein 5B (ARID5B), Truncated

Uniprot Id

Q14865

Target Species

Human

Target Name

ARID5B

Target Full Name

AT-rich interactive domain-containing protein 5B

Target Function

Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer

Target Involvement

Leukemia, acute lymphoblastic (ALL)

Target Subcellular Location

Nucleus.

Target Protein Families

ARID5B family

Target Tissue Specificity

Widely expressed, including in liver (at protein level).

Target Synonyms

ARI5B_HUMAN; ARID domain-containing protein 5B; Arid5b; AT rich interactive domain 5B (MRF1 like); AT-rich interactive domain-containing protein 5B; DESRT; FLJ21150; FLJ41888; Modulator recognition factor 2 (MRF2); Modulator recognition factor 2; MRF-2; Mrf1-like; MRF1-like protein; MRF2; OTTHUMP00000019668; RP11 341A19.1