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Recombinant Human Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G)

ACP18070

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP18070 Target NameCAMK2G
Target SynonymsCAMK2G; CAMK; CAMK-II; CAMKGCalcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II subunit gamma; CaMK-II subunit gamma; EC 2.7.11.17FormLyophilized powder
Expression SystemCustom Production. Please inquire and provide the desire expression system.Expression Range1-558
Protein LengthFull length proteinPurity>85% (SDS-PAGE)
Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDQ13555
Background Information
  • Uniprot Id

    Q13555

  • Target Species

    Human

  • Target Name

    CAMK2G

  • Target Full Name

    Calcium/calmodulin-dependent protein kinase type II subunit gamma

  • Target Function

    Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization. It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.

  • Target Subcellular Location

    Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side.

  • Target Protein Families

    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily

  • Target Tissue Specificity

    Expressed in skeletal muscle.

  • Target Synonyms

    CAMK2G; CAMK; CAMK-II; CAMKGCalcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II subunit gamma; CaMK-II subunit gamma; EC 2.7.11.17

  • Target Background

    The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.

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