Recombinant Human Zinc finger protein 638 (ZNF638), Truncated

Uniprot Id

Q14966

Target Species

Human

Target Name

ZNF638

Target Full Name

Zinc finger protein 638

Target Function

Transcription factor that binds to cytidine clusters in double-stranded DNA. Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4. Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1. May also regulate alternative splicing of target genes during adipogenesis.

Target Subcellular Location

Nucleus speckle.

Target Research Area

Others

Target Synonyms

CTCL tumor antigen se33 1; CTCL-associated antigen se33-1; Cutaneous T cell lymphoma associated antigen se33 1; Cutaneous T-cell lymphoma-associated antigen se33-1; DKFZp686P1231; MGC26130; MGC90196; NP220; NP220 nuclear protein; Nuclear protein 220; ZFML; Zfp638; Zinc finger matrin like; Zinc finger matrin like protein; Zinc finger matrin-like protein; Zinc finger protein 638; ZN638_HUMAN; ZNF 638; Znf638

Target Background

The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.