Recombinant Human Neuroplastin (NPTN), Truncated

Uniprot Id

Q9Y639

Target Species

Human

Target Name

NPTN

Target Full Name

Neuroplastin

Target Function

Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity. Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity. Promotes localization of XKR8 at the cell membrane.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell junction, synapse, postsynaptic density.

Target Tissue Specificity

Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain cortex and cerebellum (at protein level).

Target Synonyms

GP55; GP65; Neuroplastin; np55; np65; Nptn; NPTN_HUMAN; SDFR1; SDR-1; SDR1; stromal cell derived factor receptor 1; Stromal cell-derived receptor 1

Target Background

This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants.