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| Cat.No | ACP19557 | Target Name | GLDN |
|---|---|---|---|
| Target Synonyms | GLDN; COLM; UNQ9339/PRO34011Gliomedin [Cleaved into: Gliomedin shedded ectodomain] | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6ZMI3 |
|---|
Uniprot Id
Q6ZMI3
Target Species
Human
Target Name
GLDN
Target Full Name
Gliomedin
Target Function
Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier
Target Involvement
Lethal congenital contracture syndrome 11 (LCCS11)
Target Subcellular Location
Cell membrane; Single-pass type II membrane protein. Cell projection, axon.; [Gliomedin shedded ectodomain]: Secreted. Secreted, extracellular space, extracellular matrix.
Target Tissue Specificity
Specifically expressed in spinal cord, brain, placenta and sciatic nerve. More abundant in peripheral than central nervous system.
Target Synonyms
GLDN; COLM; UNQ9339/PRO34011Gliomedin [Cleaved into: Gliomedin shedded ectodomain]
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