Recombinant Human Thyrotropin subunit beta (TSHB)

Uniprot Id

P01222

Target Species

Human

Target Name

TSHB

Target Full Name

Thyrotropin subunit beta

Target Function

Indispensable for the control of thyroid structure and metabolism.

Target Subcellular Location

Secreted.

Target Protein Families

Glycoprotein hormones subunit beta family

Target Research Area

Signal Transduction

Target Synonyms

TSHBThyrotropin subunit beta; Thyroid-stimulating hormone subunit beta; TSH-B; TSH-beta; Thyrotropin beta chain; Thyrotropin alfa

Target Background

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants.