Recombinant Human Lysine-specific demethylase PHF2 (PHF2), Truncated

Uniprot Id

O75151

Target Species

Human

Target Name

PHF2

Target Full Name

Lysine-specific demethylase PHF2

Target Function

Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters

Target Subcellular Location

Nucleus, nucleolus. Chromosome, centromere, kinetochore.

Target Protein Families

JHDM1 histone demethylase family, JHDM1D subfamily

Target Tissue Specificity

Widely expressed, including in liver (at protein level).

Target Synonyms

CENP-35; GRC5; JHDM1E; Jumonji C domain containing histone demethylase 1E ; Lysine-specific demethylase PHF2; PHD finger protein 2; Phf2; PHF2_HUMAN