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| Cat.No | ACP21152 | Target Name | RP2 |
|---|---|---|---|
| Target Synonyms | RP2; Protein XRP2 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 2-350 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O75695 |
|---|
Uniprot Id
O75695
Target Species
Human
Target Name
RP2
Target Full Name
Protein XRP2
Target Function
Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.
Target Involvement
Retinitis pigmentosa 2 (RP2)
Target Subcellular Location
Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, cilium.
Target Protein Families
TBCC family
Target Tissue Specificity
Ubiquitous. Expressed in the rod and cone photoreceptors, extending from the tips of the outer segment (OS) through the inner segment (IS) and outer nuclear layer (ONL) and into the synaptic terminals of the outer plexiform layer (ONL). Also detected in t
Target Research Area
Neuroscience
Target Synonyms
RP2; Protein XRP2
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