Recombinant Human Mitochondrial import inner membrane translocase subunit Tim10 (TIMM10)

Uniprot Id

P62072

Target Species

Human

Target Name

TIMM10

Target Full Name

Mitochondrial import inner membrane translocase subunit Tim10

Target Function

Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.

Target Subcellular Location

Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side.

Target Protein Families

Small Tim family

Target Tissue Specificity

Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle.

Target Synonyms

TIMM10; TIM10; Mitochondrial import inner membrane translocase subunit Tim10

Target Background

The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins.