Recombinant Human Paired mesoderm homeobox protein 1 (PRRX1)

Uniprot Id

P54821

Target Species

Human

Target Name

PRRX1

Target Full Name

Paired mesoderm homeobox protein 1

Target Function

Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer.

Target Involvement

Agnathia-otocephaly complex (AGOTC)

Target Subcellular Location

Nucleus.

Target Protein Families

Paired homeobox family

Target Synonyms

AGOTC; Homeobox protein PHOX1; Paired mesoderm homeo box 1; Paired mesoderm homeobox 1; paired mesoderm homeobox 1 isoform pmx-1b; Paired mesoderm homeobox protein 1; Paired related homeobox 1; Paired related homeobox protein 1; Paired-related homeobox protein 1; PHOX 1; PHOX1 1, 2; PHOX1; PMX 1; PMX1; PRRX 1; Prrx1; PRRX1_HUMAN; PRX 1 ; PRX-1; PRX1

Target Background

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns.