Recombinant Human Pituitary-specific positive transcription factor 1 (POU1F1)

Uniprot Id

P28069

Target Species

Human

Target Name

POU1F1

Target Full Name

Pituitary-specific positive transcription factor 1

Target Function

Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5'-TAAAT-3'. Activates growth hormone and prolactin genes.

Target Involvement

Pituitary hormone deficiency, combined, 1 (CPHD1)

Target Subcellular Location

Nucleus.

Target Protein Families

POU transcription factor family, Class-1 subfamily

Target Synonyms

Dwarf; GHF 1; GHF 1A; GHF-1; GHF1; GHF1A; Growth hormone factor 1; Hmp 1; Hmp1; Pit 1; Pit 1 beta; PIT 1Z; PiT-1; Pit1 beta; PIT1_HUMAN; PIT1Z; Pituitary growth hormone; Pituitary specific positive transcription factor 1; Pituitary-specific positive transcription factor 1; POU class 1 homeobox 1; POU domain class 1 transcription factor 1; POU domain transcriptional regulator; POU1F1

Target Background

This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.