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The antibody against NOSIP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-301 of human NOSIP (NP_057037.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against NOSIP was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-301 of human NOSIP (NP_057037.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01194A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NOSIP |
| Target Synonyms | CGI-25; NOSIP | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, A-549, B cells | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-301 of human NOSIP (NP_057037.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9Y314 | Immunogen Sequence |
Uniprot Id
Q9Y314
Target Species
Human
Target Name
NOSIP
Target Full Name
Nitric oxide synthase-interacting protein
Target Function
E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB. Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
Target Subcellular Location
Cytoplasm. Nucleus. Note=Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle (PubMed:16135813).
Target Protein Families
NOSIP family
Target Tissue Specificity
Expressed in heart, brain and lung. Present in endothelial cells (at protein level).
Target Synonyms
NOSIP; CGI-25; Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase NOSIP; EC 2.3.2.27; RING-type E3 ubiquitin transferase NOSIP; eNOS-interacting protein
Target Background
The protein encoded by this gene may modulate the activity and localization of nitric oxide synthase (endothelial and neuronal) and thus nitric oxide production. Alternative splicing results in multiple transcript variants that encode the same protein.
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