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The antibody against MEP1B was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 480-652 of human MEP1B (NP_005916.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against MEP1B was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 480-652 of human MEP1B (NP_005916.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01251A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MEP1B |
| Target Synonyms | MEP1B | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 480-652 of human MEP1B (NP_005916.2). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | ISGANDDQLQWPCPWQQATMTLLDQNPDIRQRMSNQRSITTDPFMTTDNGNYFWDRPSKVGTVALFSNGTQFRRGGGYGTSAFITHERLKSRDFIKGDDVYILLTVEDISHLNSTQIQLTPAPSVQDLCSKTTCKNDGVCTVRDGKAECRCQSGEDWWYMGERCEKRGSTRDT | Uniprot ID | Q16820 |
Uniprot Id
Q16820
Target Species
Human
Target Name
MEP1B
Target Full Name
Meprin A subunit beta
Target Function
Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein. Secreted.
Target Protein Families
Peptidase M12A family
Target Tissue Specificity
The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells.
Target Synonyms
Endopeptidase 2 ; Endopeptidase-2; kinase splitting membranal proteinase; KSMP; Mep1b; MEP1B_HUMAN; Meprin 1 beta subunit; Meprin A beta; Meprin A beta subunit precursor; Meprin A subunit beta; Meprin B; N benzoyl L tyrosyl P amino benzoic acid hydrolase beta subunit; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta; PABA peptide hydrolase; PPH beta
Target Background
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine.
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